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Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

Activation of phosphatidylinositol-3-kinase (PI3K) is one of the earliest postreceptor events in the insulin signaling pathway. Incubation of soleus muscles from lean mice with 50 nM insulin caused a 3-10-fold increase in antiphosphotyrosine-immunoprecipitable PI3K (antiPTyr-PI3K) activity within 2...

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Bibliografiske detaljer
Main Authors: Heydrick, S J, Jullien, D, Gautier, N, Tanti, J F, Giorgetti, S, Van Obberghen, E, Le Marchand-Brustel, Y
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC288107/
https://ncbi.nlm.nih.gov/pubmed/8386184
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