Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

Activation of phosphatidylinositol-3-kinase (PI3K) is one of the earliest postreceptor events in the insulin signaling pathway. Incubation of soleus muscles from lean mice with 50 nM insulin caused a 3-10-fold increase in antiphosphotyrosine-immunoprecipitable PI3K (antiPTyr-PI3K) activity within 2...

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Pubblicato in:	J Clin Invest
Autori principali:	Heydrick, S J, Jullien, D, Gautier, N, Tanti, J F, Giorgetti, S, Van Obberghen, E, Le Marchand-Brustel, Y
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386184/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116337
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