Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

BACKGROUND: Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to ameliorate the course of relapsing-remitting MS. Glial c...

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Hlavní autoři: Wilms, Henrik, Sievers, Jobst, Rickert, Uta, Rostami-Yazdi, Martin, Mrowietz, Ulrich, Lucius, Ralph
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880998/
https://ncbi.nlm.nih.gov/pubmed/20482831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-30
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