Utilizing elementary mode analysis, pathway thermodynamics, and a genetic algorithm for metabolic flux determination and optimal metabolic network design

BACKGROUND: Microbial hosts offer a number of unique advantages when used as production systems for both native and heterologous small-molecules. These advantages include high selectivity and benign environmental impact; however, a principal drawback is low yield and/or productivity, which limits ec...

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Bibliographic Details
Main Authors: Boghigian, Brett A, Shi, Hai, Lee, Kyongbum, Pfeifer, Blaine A
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880971/
https://ncbi.nlm.nih.gov/pubmed/20416071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-49
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