Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal

The nuclear receptor TLX (also known as NR2E1) is essential for adult neural stem cell self-renewal; however, the molecular mechanisms involved remain elusive. Here we show that TLX activates the canonical Wnt/β-catenin pathway in adult mouse neural stem cells. Furthermore, we demonstrate that Wnt/β...

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Hauptverfasser: Qu, Qiuhao, Sun, Guoqiang, Li, Wenwu, Yang, Su, Ye, Peng, Zhao, Chunnian, Yu, Ruth T., Gage, Fred H., Evans, Ronald M., Shi, Yanhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880892/
https://ncbi.nlm.nih.gov/pubmed/20010817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2001
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