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Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth
Biologically active membrane gangliosides, expressed and released by many human tumors, are hypothesized to significantly impact tumor progression. Lack of a model of complete and specific tumor ganglioside depletion in vivo, however, has hampered elucidation of their role. Here we report the creati...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880627/ https://ncbi.nlm.nih.gov/pubmed/20305696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.85 |
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