Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

β-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if β-amyloid contributes to intellectual disability in younger individuals. We used a γ-secretase inhibit...

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מידע ביבליוגרפי
Main Authors: Netzer, William J., Powell, Craig, Nong, Yi, Blundell, Jacqueline, Wong, Lili, Duff, Karen, Flajolet, Marc, Greengard, Paul
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2010
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880593/
https://ncbi.nlm.nih.gov/pubmed/20532168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010943
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