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Evidence for Copper-dioxygen Reactivity during α-Synuclein Fibril Formation
α-Synuclein (α-syn), a presynaptic protein implicated in Parkinson’s disease, binds copper(II) ion (1:1) with submicromolar affinity in vitro. Insights on the molecular details of soluble-and fibrillar-Cu-α-syn are gained through X-ray absorption spectroscopy. Our results indicate that the copper co...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880511/ https://ncbi.nlm.nih.gov/pubmed/20423081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja101756m |
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