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Review: Bilirubin pKa studies; new models and theories indicate high pKa values in water, dimethylformamide and DMSO

BACKGROUND: Correct aqueous pKa values of unconjugated bilirubin (UCB), a poorly-soluble, unstable substance, are essential for understanding its functions. Our prior solvent partition studies, of unlabeled and [(14)C] UCB, indicated pKa values above 8.0. These high values were attributed to effects...

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Detalhes bibliográficos
Main Authors: Mukerjee, Pasupati, Ostrow, J Donald
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880415/
https://ncbi.nlm.nih.gov/pubmed/20350305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-11-15
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