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Calculating pKa values in enzyme active sites

The ionization properties of the active-site residues in enzymes are of considerable interest in the study of the catalytic mechanisms of enzymes. Knowledge of these ionization constants (pKa values) often allows the researcher to identify the proton donor and the catalytic nucleophile in the reacti...

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Bibliographic Details
Main Authors: Nielsen, Jens Erik, McCammon, J. Andrew
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323987/
https://ncbi.nlm.nih.gov/pubmed/12930989
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