Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

BACKGROUND: To investigate the etiology of MLH1 promoter methylation in mismatch repair (MMR) mutation-negative early onset MSI-H colon cancer. As this type of colon cancer is associated with high ages, young patients bearing this type of malignancy are rare and could provide additional insight into...

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Hauptverfasser: van Roon, Eddy HJ, van Puijenbroek, Marjo, Middeldorp, Anneke, van Eijk, Ronald, de Meijer, Emile J, Erasmus, Dianhdra, Wouters, Kim AD, van Engeland, Manon, Oosting, Jan, Hes, Frederik J, Tops, Carli MJ, van Wezel, Tom, Boer, Judith M, Morreau, Hans
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880297/
https://ncbi.nlm.nih.gov/pubmed/20444249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-180
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