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Hsk1- and SCF(Pof3)-Dependent Proteolysis of S. pombe Ams2 Ensures Histone Homeostasis and Centromere Function
Schizosaccharomyces pombe GATA factor Ams2 is responsible for cell cycle-dependent transcriptional activation of all the core histone genes peaking at G1/S phase. Intriguingly, its own protein level also fluctuates concurrently. Here, we show that Ams2 is ubiquitylated and degraded through the SCF (...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880248/ https://ncbi.nlm.nih.gov/pubmed/20230746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.12.024 |
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