Hsk1- and SCF(Pof3)-Dependent Proteolysis of S. pombe Ams2 Ensures Histone Homeostasis and Centromere Function

Schizosaccharomyces pombe GATA factor Ams2 is responsible for cell cycle-dependent transcriptional activation of all the core histone genes peaking at G1/S phase. Intriguingly, its own protein level also fluctuates concurrently. Here, we show that Ams2 is ubiquitylated and degraded through the SCF (...

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Main Authors: Takayama, Yuko, Mamnun, Yasmine M., Trickey, Michelle, Dhut, Susheela, Masuda, Fumie, Yamano, Hiroyuki, Toda, Takashi, Saitoh, Shigeaki
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880248/
https://ncbi.nlm.nih.gov/pubmed/20230746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.12.024
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