Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis

BACKGROUND: Previous observations demonstrate that Cftr-null cells and tissues exhibit alterations in cholesterol processing including perinuclear cholesterol accumulation, increased de novo synthesis, and an increase in plasma membrane cholesterol accessibility compared to wild type controls. The h...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Fang, Danjun, West, Richard H, Manson, Mary E, Ruddy, Jennifer, Jiang, Dechen, Previs, Stephen F, Sonawane, Nitin D, Burgess, James D, Kelley, Thomas J
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880018/
https://ncbi.nlm.nih.gov/pubmed/20487541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-61
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