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In Vitro Glucuronidation of 2,2-Bis(bromomethyl)-1,3-propanediol by Microsomes and Hepatocytes from Rats and Humans

2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant used in unsaturated polyester resins. In a 2-year bioassay BMP was shown to be a multisite carcinogen in rats and mice. Because glucuronidation is the key metabolic transformation of BMP by rats, in this study the in vitro he...

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Detalhes bibliográficos
Main Authors: Rad, Golriz, Hoehle, Simone I., Kuester, Robert K., Sipes, I. Glenn
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879955/
https://ncbi.nlm.nih.gov/pubmed/20200232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.032110
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