Actin-Bundling Protein TRIOBP Forms Resilient Rootlets of Hair Cell Stereocilia That Are Essential for Hearing

Inner ear hair cells detect sound through deflection of mechanosensory stereocilia. Each stereocilium is supported by a paracrystalline array of parallel actin filaments that are packed more densely at the base, forming a rootlet extending into the cell body. The function of rootlets and the molecul...

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Main Authors: Kitajiri, Shin-ichiro, Sakamoto, Takeshi, Belyantseva, Inna A., Goodyear, Richard J., Stepanyan, Ruben, Fujiwara, Ikuko, Bird, Jonathan E., Riazuddin, Saima, Riazuddin, Sheikh, Ahmed, Zubair M., Hinshaw, Jenny E., Sellers, James, Bartles, James R., Hammer, John A., Richardson, Guy P., Griffith, Andrew J., Frolenkov, Gregory I., Friedman, Thomas B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879707/
https://ncbi.nlm.nih.gov/pubmed/20510926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.03.049
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