Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex

Upon activation of the ERK and p38 MAPK pathways, the MSK1/2-mediated nucleosomal response, including H3 phosphorylation at serine 28 or 10, is coupled with the induction of immediate-early (IE) gene transcription. The outcome of this response, varying with the stimuli and cellular contexts, ranges...

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Main Authors: Drobic, Bojan, Pérez-Cadahía, Beatriz, Yu, Jenny, Kung, Sam Kam-Pun, Davie, James R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879512/
https://ncbi.nlm.nih.gov/pubmed/20129940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq030
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