Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription

Activity of the sodium/iodide symporter (NIS) in lactating breast is essential for iodide (I(–)) accumulation in milk. Significant NIS upregulation was also reported in breast cancer, indicating a potential use of radioiodide treatment. All-trans-retinoic acid (tRA) is a potent ligand that enhances...

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Detalhes bibliográficos
Main Authors: Alotaibi, Hani, Yaman, Elif, Salvatore, Domenico, Di Dato, Valeria, Telkoparan, Pelin, Di Lauro, Roberto, Tazebay, Uygar H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879507/
https://ncbi.nlm.nih.gov/pubmed/20123735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq023
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