Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-Methoxy-N,N-dimethyltryptamine Metabolism and Pharmacokinetics

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural psychoactive indolealkylamine drug that has been used for recreational purpose. Our previous study revealed that polymorphic cytochrome P450 2D6 (CYP2D6) catalyzed 5-MeO-DMT O-demethylation to produce active metabolite bufotenine, while 5-MeO...

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Hlavní autoři: Shen, Hong-Wu, Wu, Chao, Jiang, Xi-Ling, Yu, Ai-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879007/
https://ncbi.nlm.nih.gov/pubmed/20206139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.02.020
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