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Apparent Activity in High-Throughput Screening: Origins of Compound-Dependent Assay Interference

Expansive compound collections made up of structurally heterogeneous chemicals, the activities of which are largely undefined, present challenging problems for high-throughput screening (HTS). Foremost is differentiating whether the activity for a given compound in an assay is directed against the t...

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Detalhes bibliográficos
Main Authors: Thorne, Natasha, Auld, Douglas S., Inglese, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878863/
https://ncbi.nlm.nih.gov/pubmed/20417149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2010.03.020
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