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Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells

BACKGROUND: Tyrosine kinase inhibitors, such as imatinib, are not considered curative for chronic myeloid leukemia – regardless of the significant reduction of disease burden during treatment – since they do not affect the leukemic stem cells. However, the stochastic nature of hematopoiesis and rece...

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Bibliografski detalji
Glavni autori: Lenaerts, Tom, Pacheco, Jorge M., Traulsen, Arne, Dingli, David
Format: Artigo
Jezik:Inglês
Izdano: Ferrata Storti Foundation 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878786/
https://ncbi.nlm.nih.gov/pubmed/20007137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.015271
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