Scaffold Proteins IRSp53 and Spinophilin Regulate Localized Rac Activation by T-lymphocyte Invasion and Metastasis Protein 1 (TIAM1)

The Rac exchange factor Tiam1 is involved in diverse cell functions and signaling pathways through multiple protein interactions, raising the question of how signaling and functional specificity are achieved. We have shown that Tiam1 interactions with different scaffold proteins activate different R...

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Detalhes bibliográficos
Main Authors: Rajagopal, Soumitra, Ji, Yuxin, Xu, Kun, Li, Yuhuan, Wicks, Kathleen, Liu, Jiewei, Wong, Ka-Wing, Herman, Ira M., Isberg, Ralph R., Buchsbaum, Rachel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878567/
https://ncbi.nlm.nih.gov/pubmed/20360004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051490
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