Cis and Trans Actions of the Cholinesterase-like Domain within the Thyroglobulin Dimer

Thyroglobulin (Tg, precursor for thyroid hormone synthesis) is a large secreted glycoprotein composed of upstream regions I-II-III, followed by the ∼570 residue cholinesterase-like (ChEL) domain. ChEL has two identified functions: 1) homodimerization, and 2) binding to I-II-III that facilitates I-II...

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Главные авторы: Wang, Xiaofan, Lee, Jaemin, Di Jeso, Bruno, Treglia, A. Sonia, Comoletti, Davide, Dubi, Noga, Taylor, Palmer, Arvan, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878521/
https://ncbi.nlm.nih.gov/pubmed/20353937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111641
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