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Cis and Trans Actions of the Cholinesterase-like Domain within the Thyroglobulin Dimer
Thyroglobulin (Tg, precursor for thyroid hormone synthesis) is a large secreted glycoprotein composed of upstream regions I-II-III, followed by the ∼570 residue cholinesterase-like (ChEL) domain. ChEL has two identified functions: 1) homodimerization, and 2) binding to I-II-III that facilitates I-II...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878521/ https://ncbi.nlm.nih.gov/pubmed/20353937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111641 |
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