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The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone
Thyroid hormonogenesis requires secretion of thyroglobulin, a protein comprising Cys-rich regions I, II, and III (referred to collectively as region I-II-III) followed by a cholinesterase-like (ChEL) domain. Secretion of mature thyroglobulin requires extensive folding and glycosylation in the ER. Mu...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Clinical Investigation
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2441857/ https://ncbi.nlm.nih.gov/pubmed/18596923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35164 |
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