Bayesian methods for instrumental variable analysis with genetic instruments (‘Mendelian randomization’): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome

The ‘Mendelian randomization’ approach uses genotype as an instrumental variable to distinguish between causal and non-causal explanations of biomarker–disease associations. Classical methods for instrumental variable analysis are limited to linear or probit models without latent variables or missin...

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Podrobná bibliografie
Hlavní autoři: McKeigue, Paul M, Campbell, Harry, Wild, Sarah, Vitart, Veronique, Hayward, Caroline, Rudan, Igor, Wright, Alan F, Wilson, James F
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Methods
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878456/
https://ncbi.nlm.nih.gov/pubmed/20348110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyp397
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