Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies

BACKGROUND: Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in general versus a specific effect on prostate can...

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Main Authors: Elliott, Katherine S., Zeggini, Eleftheria, McCarthy, Mark I., Gudmundsson, Julius, Sulem, Patrick, Stacey, Simon N., Thorlacius, Steinunn, Amundadottir, Laufey, Grönberg, Henrik, Xu, Jianfeng, Gaborieau, Valerie, Eeles, Rosalind A., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Muir, Kenneth, Hwang, Shih-Jen, Spitz, Margaret R., Zanke, Brent, Carvajal-Carmona, Luis, Brown, Kevin M., Hayward, Nicholas K., Macgregor, Stuart, Tomlinson, Ian P. M., Lemire, Mathieu, Amos, Christopher I., Murabito, Joanne M., Isaacs, William B., Easton, Douglas F., Brennan, Paul, Barkardottir, Rosa B., Gudbjartsson, Daniel F., Rafnar, Thorunn, Hunter, David J., Chanock, Stephen J., Stefansson, Kari, Ioannidis, John P. A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878330/
https://ncbi.nlm.nih.gov/pubmed/20526366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010858
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