Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity

BACKGROUND: Systemic lupus erythematosus (SLE), an autoimmune disease, predominantly affects women of childbearing age. Moreover, increased serum levels of interferon-α (IFN-α) are associated with the disease. Although, the female sex hormone estrogen (E2) is implicated in sex bias in SLE through up...

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Bibliographic Details
Main Authors: Panchanathan, Ravichandran, Shen, Hui, Zhang, Xiang, Ho, Shuk-mei, Choubey, Divaker
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878324/
https://ncbi.nlm.nih.gov/pubmed/20526365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010868
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