Mutually Positive Regulatory Feedback Loop between Interferons and Estrogen Receptor-α in Mice: Implications for Sex Bias in Autoimmunity

BACKGROUND: Systemic lupus erythematosus (SLE), an autoimmune disease, predominantly affects women of childbearing age. Moreover, increased serum levels of interferon-α (IFN-α) are associated with the disease. Although, the female sex hormone estrogen (E2) is implicated in sex bias in SLE through up...

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Hlavní autoři: Panchanathan, Ravichandran, Shen, Hui, Zhang, Xiang, Ho, Shuk-mei, Choubey, Divaker
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878324/
https://ncbi.nlm.nih.gov/pubmed/20526365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010868
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