Structure of a DNA Polymerase α-Primase Domain That Docks on the SV40 Helicase and Activates the Viral Primosome

DNA polymerase α-primase (pol-prim) plays a central role in DNA replication in higher eukaryotes, initiating synthesis on both leading and lagging strand single-stranded DNA templates. Pol-prim consists of a primase heterodimer that synthesizes RNA primers, a DNA polymerase that extends them, and a...

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Main Authors: Huang, Hao, Weiner, Brian E., Zhang, Haijiang, Fuller, Brian E., Gao, Yue, Wile, Brian M., Zhao, Kun, Arnett, Diana R., Chazin, Walter J., Fanning, Ellen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878050/
https://ncbi.nlm.nih.gov/pubmed/20234039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116830
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