Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or reoxygenated A431 carcinoma cells exhibited enhanced angiogenic and metastatic potential such as reduced cell-cell and cell-extracel...

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Detalhes bibliográficos
Main Authors: Park, Jung Eun, Tan, Hon Sen, Datta, Arnab, Lai, Ruenn Chai, Zhang, Huoming, Meng, Wei, Lim, Sai Kiang, Sze, Siu Kwan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877972/
https://ncbi.nlm.nih.gov/pubmed/20124223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900381-MCP200
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