Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion

Epithelial-mesenchymal interactions regulate normal gut epithelial homeostasis and have a putative role in inflammatory bowel disease and colon cancer pathogenesis. Epimorphin is a mesenchymal and myofibroblast protein with antiproliferative, promorphogenic effects in intestinal epithelium. We previ...

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Bibliographische Detailangaben
Hauptverfasser: Shaker, Anisa, Swietlicki, Elzbieta A., Wang, Lihua, Jiang, Shujun, Onal, Birce, Bala, Shashi, DeSchryver, Katherine, Newberry, Rodney, Levin, Marc S., Rubin, Deborah C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877942/
https://ncbi.nlm.nih.gov/pubmed/20458144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40676
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