The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

Activated protein C (APC), the only FDA-approved biotherapeutic drug for sepsis, possesses anticoagulant, antiinflammatory, and barrier-protective activities. However, the mechanisms underlying its anti­inflammatory functions are not well defined. Here, we report that the antiinflammatory activity o...

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Detalhes bibliográficos
Main Authors: Cao, Chunzhang, Gao, Yamei, Li, Yang, Antalis, Toni M., Castellino, Francis J., Zhang, Li
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877939/
https://ncbi.nlm.nih.gov/pubmed/20458145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40380
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