Tumor Progression Stage and Anatomical Site Regulate Tumor-Associated Macrophage and Bone Marrow-Derived Monocyte Polarization

Tumor-associated macrophages (TAMs) encourage and coordinate neoplastic growth. In late stage human lung adenocarcinoma, TAMs exhibited mixed M1 (classical; argI(low)iNOS(high)) and M2 (alternative; argI(high)iNOS(low)) polarization based on arginine metabolism. In several murine cancer models inclu...

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Detalhes bibliográficos
Main Authors: Redente, Elizabeth F., Dwyer-Nield, Lori D., Merrick, Daniel T., Raina, Komal, Agarwal, Rajesh, Pao, William, Rice, Pamela L., Shroyer, Kenneth R., Malkinson, Alvin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877857/
https://ncbi.nlm.nih.gov/pubmed/20431028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090879
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