Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation

Nucleophosmin (NPM), an oligomeric phosphoprotein and nucleolar target of the ARF tumor suppressor, contributes to several critical cellular processes. Previous studies have shown that the human NPM’s phosphorylation by cyclin E–cyclin-dependent kinase 2 (cdk2) on threonine (Thr) 199 regulates its t...

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Bibliographic Details
Main Authors: Brady, SN, Maggi, LB, Winkeler, CL, Toso, EA, Gwinn, AS, Pelletier, CL, Weber, JD
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877400/
https://ncbi.nlm.nih.gov/pubmed/19561638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.178
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