Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation

Nucleophosmin (NPM), an oligomeric phosphoprotein and nucleolar target of the ARF tumor suppressor, contributes to several critical cellular processes. Previous studies have shown that the human NPM’s phosphorylation by cyclin E–cyclin-dependent kinase 2 (cdk2) on threonine (Thr) 199 regulates its t...

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Autores principales: Brady, SN, Maggi, LB, Winkeler, CL, Toso, EA, Gwinn, AS, Pelletier, CL, Weber, JD
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877400/
https://ncbi.nlm.nih.gov/pubmed/19561638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.178
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