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Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation
Nucleophosmin (NPM), an oligomeric phosphoprotein and nucleolar target of the ARF tumor suppressor, contributes to several critical cellular processes. Previous studies have shown that the human NPM’s phosphorylation by cyclin E–cyclin-dependent kinase 2 (cdk2) on threonine (Thr) 199 regulates its t...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877400/ https://ncbi.nlm.nih.gov/pubmed/19561638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.178 |
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