Long-Lived Plasma Cells and Memory B Cells Produce Pathogenic Anti-GAD65 Autoantibodies in Stiff Person Syndrome

Stiff person syndrome (SPS) is a rare, neurological disorder characterized by sudden cramps and spasms. High titers of enzyme-inhibiting IgG autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65) are a hallmark of SPS, implicating an autoimmune component in the pathology of...

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Detalhes bibliográficos
Main Authors: Rizzi, Marta, Knoth, Rolf, Hampe, Christiane S., Lorenz, Peter, Gougeon, Marie-Lise, Lemercier, Brigitte, Venhoff, Nils, Ferrera, Francesca, Salzer, Ulrich, Thiesen, Hans-Jürgen, Peter, Hans-Hartmut, Walker, Ulrich A., Eibel, Hermann
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877104/
https://ncbi.nlm.nih.gov/pubmed/20520773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010838
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