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An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs
The gene mutated in Bloom's syndrome, BLM, encodes a member of the RecQ family of DNA helicases that is needed to suppress genome instability and cancer predisposition. BLM is highly conserved and all BLM orthologs, including budding yeast Sgs1, have a large N-terminus that binds Top3–Rmi1 but...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2876966/ https://ncbi.nlm.nih.gov/pubmed/20389284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.61 |
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