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An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs

The gene mutated in Bloom's syndrome, BLM, encodes a member of the RecQ family of DNA helicases that is needed to suppress genome instability and cancer predisposition. BLM is highly conserved and all BLM orthologs, including budding yeast Sgs1, have a large N-terminus that binds Top3–Rmi1 but...

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Hlavní autoři: Chen, Chi-Fu, Brill, Steven J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876966/
https://ncbi.nlm.nih.gov/pubmed/20389284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.61
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