Inhibiting the ubiquitin–proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

Lignende værker

• Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation
  af: Havel, Lauren S., et al.
  Udgivet: (2011)
• Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues
  af: Wade, Brandy E., et al.
  Udgivet: (2014)
• Differential Activities of the Ubiquitin–Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons
  af: Tydlacka, Suzanne, et al.
  Udgivet: (2008)
• Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A
  af: Bhat, Kavita P., et al.
  Udgivet: (2014)
• Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes
  af: Zhao, Ting, et al.
  Udgivet: (2016)