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An Antibody Directed against the Fusion Peptide of Junín Virus Envelope Glycoprotein GPC Inhibits pH-Induced Membrane Fusion

The arenavirus envelope glycoprotein (GPC) initiates infection in the host cell through pH-induced fusion of the viral and endosomal membranes. As in other class I viral fusion proteins, this process proceeds through a structural reorganization in GPC in which the ectodomain of the transmembrane fus...

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Autors principals: York, Joanne, Berry, Jody D., Ströher, Ute, Li, Qunnu, Feldmann, Heinz, Lu, Min, Trahey, Meg, Nunberg, Jack H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876654/
https://ncbi.nlm.nih.gov/pubmed/20392854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02700-09
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