2A Protease Is Not a Prerequisite for Poliovirus Replication

Poliovirus (PV) 2A(pro) has been considered important for PV replication and is known to be toxic to host cells. A 2A(pro)-deficient PV would potentially be less toxic and ideal as a vector. To examine whether 2A(pro) is needed to form progeny virus, a full-length cDNA of dicistronic (dc) PV with (p...

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Hlavní autoři: Igarashi, Hiroko, Yoshino, Yasuko, Miyazawa, Miwako, Horie, Hitoshi, Ohka, Seii, Nomoto, Akio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876632/
https://ncbi.nlm.nih.gov/pubmed/20392856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02575-09
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