Fine-Tuning Synthesis of Yersinia pestis LcrV from Runaway-Like Replication Balanced-Lethal Plasmid in a Salmonella enterica Serovar Typhimurium Vaccine Induces Protection against a Lethal Y. pestis Challenge in Mice

A balanced-lethal plasmid expression system that switches from low-copy-number to runaway-like high-copy-number replication (pYA4534) was constructed for the regulated delayed in vivo synthesis of heterologous antigens by vaccine strains. This is an antibiotic resistance-free maintenance system cont...

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Detalhes bibliográficos
Main Authors: Torres-Escobar, Ascención, Juárez-Rodríguez, María Dolores, Gunn, Bronwyn M., Branger, Christine G., Tinge, Steven A., Curtiss, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876574/
https://ncbi.nlm.nih.gov/pubmed/20308296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00005-10
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