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Population Pharmacokinetics of Doripenem Based on Data from Phase 1 Studies with Healthy Volunteers and Phase 2 and 3 Studies with Critically Ill Patients

A population pharmacokinetic model of doripenem was constructed using data pooled from phase 1, 2, and 3 studies utilizing nonlinear mixed effects modeling. A 2-compartment model with zero-order input and first-order elimination best described the log-transformed concentration-versus-time profile of...

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Bibliografske podrobnosti
Main Authors: Nandy, Partha, Samtani, Mahesh N., Lin, Rachel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876402/
https://ncbi.nlm.nih.gov/pubmed/20385854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01649-09
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