Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease

Small-molecule hepatitis C virus (HCV) NS3 protease inhibitors such as boceprevir (SCH 503034) have been shown to have antiviral activity when they are used as monotherapy and in combination with pegylated alpha interferon and ribavirin in clinical trials. Improvements in inhibitor potency and pharm...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tong, X., Arasappan, A., Bennett, F., Chase, R., Feld, B., Guo, Z., Hart, A., Madison, V., Malcolm, B., Pichardo, J., Prongay, A., Ralston, R., Skelton, A., Xia, E., Zhang, R., Njoroge, F. G.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology (ASM) 2010
विषय:
Antiviral Agents
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876368/
https://ncbi.nlm.nih.gov/pubmed/20308381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00135-10
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