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Ephedrine treatment in congenital myasthenic syndrome due to mutations in DOK7 [Image: see text]

BACKGROUND: Mutations in the postsynaptic adaptor protein Dok-7 underlie congenital myasthenic syndrome (CMS) with a characteristic limb girdle pattern of muscle weakness. Patients usually do not respond to or worsen with the standard CMS treatments: cholinesterase inhibitors and 3,4-diaminopyridine...

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Autors principals: Lashley, D., Palace, J., Jayawant, S., Robb, S., Beeson, D.
Format: Artigo
Idioma:Inglês
Publicat: American Academy of Neurology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875925/
https://ncbi.nlm.nih.gov/pubmed/20458068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181dd43bf
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