Sensory Axon-Derived Neuregulin-1 Is Required for Axoglial Signaling and Normal Sensory Function But Not for Long-Term Axon Maintenance

Neuregulin-1 has a key role in mediating signaling between axons and Schwann cells during development. A limitation to studying its role in adulthood is the embryonic lethality of global Nrg1 gene deletion. We used the Cre-loxP system to generate transgenic mice in which neuregulin-1 is conditionall...

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Main Authors: Fricker, Florence R., Zhu, Ning, Tsantoulas, Christoforos, Abrahamsen, Bjarke, Nassar, Mohammed A., Thakur, Matthew, Garratt, Alistair N., Birchmeier, Carmen, McMahon, Stephen B., Wood, John N., Bennett, David L. H.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875847/
https://ncbi.nlm.nih.gov/pubmed/19535578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6053-08.2009
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