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Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1(+/−) Mice: A Role of Lipid Mobilization and Inflammation

Mammalian sirtuin 1 (SIRT1) may control fatty acid homeostasis in liver. However, this possibility and underlying mechanism remain to be established. In this study, we addressed the issues by examining the metabolic phenotypes of SIRT1 heterozygous knockout (SIRT1(+/−)) mice. The study was conducted...

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Main Authors: Xu, Fen, Gao, Zhanguo, Zhang, Jin, Rivera, Chantal A., Yin, Jun, Weng, Jianping, Ye, Jianping
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Endocrine Society 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875813/
https://ncbi.nlm.nih.gov/pubmed/20339025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1013
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