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Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1(+/−) Mice: A Role of Lipid Mobilization and Inflammation

Mammalian sirtuin 1 (SIRT1) may control fatty acid homeostasis in liver. However, this possibility and underlying mechanism remain to be established. In this study, we addressed the issues by examining the metabolic phenotypes of SIRT1 heterozygous knockout (SIRT1(+/−)) mice. The study was conducted...

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Bibliografische gegevens
Hoofdauteurs: Xu, Fen, Gao, Zhanguo, Zhang, Jin, Rivera, Chantal A., Yin, Jun, Weng, Jianping, Ye, Jianping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Endocrine Society 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875813/
https://ncbi.nlm.nih.gov/pubmed/20339025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1013
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