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Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1(+/−) Mice: A Role of Lipid Mobilization and Inflammation
Mammalian sirtuin 1 (SIRT1) may control fatty acid homeostasis in liver. However, this possibility and underlying mechanism remain to be established. In this study, we addressed the issues by examining the metabolic phenotypes of SIRT1 heterozygous knockout (SIRT1(+/−)) mice. The study was conducted...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Endocrine Society
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875813/ https://ncbi.nlm.nih.gov/pubmed/20339025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1013 |
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