Reduced exposure of imatinib after coadministration with acetaminophen in mice

PURPOSE: Imatinib is an efficacious drug against chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST) due to selective inhibition of c-KIT and BCR-ABL kinases. It presents almost complete bioavailability, is eliminated via P450-mediated metabolism and is well tolerated. However,...

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Bibliografske podrobnosti
Main Authors: Nassar, Inthisham, Pasupati, Thanikachalam, Judson, John Paul, Segarra, Ignacio
Format: Artigo
Jezik:Inglês
Izdano: Medknow Publications 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875735/
https://ncbi.nlm.nih.gov/pubmed/20523867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0253-7613.56071
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