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Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
INTRODUCTION: Leptin is a peptide hormone with a role in bone metabolism and rheumatic diseases. The subchondral bone tissue plays a prominent role in the pathophysiology of osteoarthritis (OA), related to abnormal osteoblast (Ob) differentiation. Although leptin promotes the differentiation of Ob u...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875652/ https://ncbi.nlm.nih.gov/pubmed/20141628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2925 |
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